iX Biopharma has completed pre-clinical development for WafeRest, a sublingual melatonin wafer supplement aimed to alleviate jet lag and improve sleep quality.

Melatonin is a hormone produced in the brain that regulates the circadian rhythm (sleep-wake cycle) and people’s ability to sleep. Research has shown that melatonin has a low absolute bioavailability either due to poor oral absorption, large first-pass metabolism, or a combination of both. The use of iX Biopharma’s WaferiX sublingual technology potentially allows for the improvement of its bioavailability as the delivery of the drug bypasses the first-pass metabolism, and hence offers a more rapid and predictable dosage of melatonin.

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