Novel sublingual CBD wafer

The Xativa Hub is an Australian patient access gateway and an information hub for GPs and specialists to find out more about current research and treatment products available in Australia.

iX Biopharma is developing a range of sublingual wafers containing cannabidiol (CBD) by using its patented sublingual delivery technology, WaferiX™.

The wafers are formulated to contain a nano-emulsion of broad-spectrum hemp oil, which comprises:

  • 70-90% CBD
  • 0.0% THC
  • Remainder made up of naturally occurring cannabinoids and terpenes found in hemp

A proprietary and patent-pending technology is used in the extraction & purification process of the hemp oil to preserve terpenes and plant lipids, while eliminating unwanted Delta-9-THC, waxes and chlorophyll.

iX is currently evaluating these CBD sublingual wafers for use in the treatment of certain conditions.

The WaferiX™ advantage for better user experience

CBD suffers from poor oral bioavailability. Sublingual delivery of CBD is fast becoming the most preferred method of consuming CBD which allows a user to maximise the benefits of CBD.

IX's WaferiX™ sublingual delivery technology is a patented formulation produced by a proprietary freeze-drying technique. The porous and amorphous WaferiX™ matrix holding the active CBD is designed to rapidly collapse and release the nanoparticles of CBD within a minute of being in contact with saliva in the sublingual space. CBD is then rapidly transported across the sublingual membrane into the blood vessels for a rapid onset of action. Read more about how WaferiX™ works [here].

The benefits of CBD delivered using the WaferiX™ technology are:

  • Disintegration within a minute
  • Fast absorption; Rapid onset of action
  • Increased bioavailability of CBD
  • Predictable absorption

It is a highly differentiated and superior offering compared to existing methods of delivering CBD. Existing delivery methods such as nasal sprays and oral capsules cause CBD to be inconsistently absorbed and is too variable or poorly bioavailable to be truly useful as a therapy.

WaferiX™ is a more elegant and convenient way to administer CBD, giving users a better experience.

Background on Medicinal Cannabis

Cannabis has a long and colourful history.

It is a plant of the Cannabaceae family and its medicinal properties have been known for millennia¹.

Cannabis was first thought to have originated from Central Asia and was used by many ancient societies.

In fact, indications for therapeutic use of cannabis were mentioned in the texts of the Indian Hindus, Assyrians, Greeks and Romans. Cannabis was described to have helped alleviate and treat many health ailments, including pain, depression, inflammation, appetite loss and asthma related problems et cetera.

How does Medicinal Cannabis work?

The Cannabis plant contains two of the most prominent cannabinoids;

Cannabidiol (CBD) and Delta-9-Tetrahydrocannabinol (THC).

Through the Endocannabinoid System in our body, CBD and THC interact to have various effects.

Non-intoxicating Intoxicating
Anti-inflammatory and reduces pain Anti-inflammatory and reduces pain
May reduce anxiety May improve appetite
Anticonvulsant Potentially reduces nausea
Regulate THC effects May help with insomnia
Image adapted from Partow, Cyrus 20194 and

The Endocannabinoid System

The endocannabinoid system (ECS) is a complex cell-signalling system found throughout our body³.

It consists of three key components, including:


  • Molecules created by our body
  • Help keep internal functions running smoothly


  • Receptors found throughout our body
  • Two key receptors
    1. CB1 - mainly found in central nervous system
    2. CB2 - mainly found in peripheral nervous system
  • Endocannabinoids bind to either receptor & effects depend on where the receptor is located


Responsible for breaking down endocannabinoids once they have served their function

The endocannabinoid system plays a critical role in balancing many processes in our body, including immune response, appetite, sleep, et cetera.

Contact us

iX Biopharma Ltd

1 Kim Seng Promenade
#14-01 Great World City East Tower
Singapore 237994
T: +65 6235 2270
F: +65 6235 2170